Rimonabant(Acomplia, Zimulti)
Rimonabant Review
Rimonabant is a new anti-obesity drug used complementary to diet and exercise to treat obese or overweight patients who suffer from Type 2 diabetes and abnormal levels of fat in the blood. It can also prevent the risk of cardiovascular disease and can help quit smoking.
Rimonabant is marketed in Europe by the name Acomplia and the same drug will be sold in United States by the name of Zimulti if approved by the FDA.
In clinical trials patients who took Rimonabant lost up to 20 pounds in weight over the course of a year. A drop in waistline measurement was also observed.
Patients followed a low calorie diet while taking the drug, and achieved better results than a control group following a low calorie diet and taking a placebo.
Most of the weight loss has been shown to occur during the first year of use.
Rimonabant may control the urge to smoke. In one study the drug was shown to double the chances of a smoker quitting successfully, at least short term.
Rimonabant may also help reduce the level of fats in the blood.
How does Rimonabant work?
Rimonabant works on the CB- 1 receptors which are present throughout the body. Rimonabant helps in blocking out these receptors which in turn works on intake of food in an individual and curbs his appetite. Weight loss starts taking place as the food intake of an individual is decreased to quite an extent. It acts on the peripheral organs which play a very important part in lipid and glucose metabolism, including the liver, adipose tissue muscles and the gastrointestinal tract.
Rimonabant - How to Take
The usual dose is one 20 mg tablet to be taken once daily in the morning before breakfast. Swallow the tablet whole.
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Rimonabant Side Effects
Side effects of this drug observed during the trials include anxiety, disorientation, insomnia, nausea, headache, hallucinations, hypertension, heart and kidney damage, palpitations, heart attack, strokes, psychosis, fatigue and hyperphagia (excessive eating beyond normal feeling of hunger), gastrointestinal discomfort and dizziness.
Rimonabant Precautions
Rimonabant should not be taken by pregnant woman since it may cause birth defects in an unborn baby.
Rimonabant should not also be used by lactating mothers. Though not clinically proved, there is possibility that this diet pill may be passed into breast milk.
Rimonabant is metabolized by the liver, so it is recommended that patients with moderate hepatic impairment should consult their healthcare provider before using the drug.
People with a history of psychiatric illness should use Rimonabant only under specialist supervision.
Rimonabant Storage
Rimonabant should be stored at room temperature in a cool and dry place. Keep away from the reach of children.
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